Research progress of mulberry twig alkaloids

doi:10.16178/j.issn.0528-9017.20230685

Abstract

Abstract:

Mulberry twig is the dry twig of Mrous alba L. in Moraceae family. It can be used to treat rheumatism and numbness of joints in traditional Chinese medicine. Modern studies have found that mulberry twig has a variety of pharmacological effects, including regulation of abnormal glucose and lipid metabolism, antioxidant, antibacterial, antiviral, etc. Alkaloids are important active components in mulberry twig, which have good hypoglycemic effect. It also regulates glycolipid metabolism and intestinal microbiota, protects islet β cells, improves glucose-stimulated insulin secretion function, and stimulates GLP-1 secretion. In this paper, the types, synthetic pathways, extraction and detection methods and pharmacological effects of mulberry twig alkaloids were reviewed. This paper aims to provide reference for further study and efficient utilization of mulberry twig alkaloids.

Key words: mulberry twig, alkaloid, biosynthesis, pharmacology

CLC Number:

S567.1+9

ZHAO Hui, ZHONG Shi, SUN Yuqing, HUO Jinxi, LI Yougui. Research progress of mulberry twig alkaloids[J]. Journal of Zhejiang Agricultural Sciences, 2024, 65(11): 2723-2732.

Figures/Tables 11

References 52

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种类	名称	参考文献
1-脱氧野尻霉素(DNJ)	1-deoxynojirimycin	[11-12]
N-甲基-l-l脱氧野尻霉素	N-methy-l-l deoxynojirimycin	[11]
4-O-β-D-吡喃葡糖基	4-O-β-D-glucopyranosyl	[11]
1,4双脱氧-1,4-亚氨基-(2-O-β-D-吡喃葡糖基)-D-阿拉伯糖醇	1,4-dideoxy-1,4-imino-(2-0-B-D-glucopyranosyl)-D-arabinitol	[12]
荞麦碱(FAG)	fagomine	[12]
3-表荞麦碱	3-epi-fagomine	[12]
打碗花精B2	calysteginB2	[12]
1,4双脱氧-1,4-亚氨基-D-阿拉伯糖醇(DAB)	1,4-dideoxy-1,4-mino-D-arabinitol	[12]
2-O-β-D-吡喃葡糖基-1-脱氧野尻霉素	2-O-(B-D-glucopyranosyl)-1-deoxynojirimycin	[12]
6-O-β-D-吡喃葡糖基-1-脱氧野尻霉素	6-O-(B-D-glucopyranosyl)-1-Deoxynojirimycin	[12]
2-O-(α-d-吡喃半乳糖基)-1-脱氧野尻霉素	2-O-(α-d-galactopyranosyl)-1-deoxynojirimycin	[12]

种类	名称	参考文献
1-脱氧野尻霉素(DNJ)	1-deoxynojirimycin	[11-12]
N-甲基-l-l脱氧野尻霉素	N-methy-l-l deoxynojirimycin	[11]
4-O-β-D-吡喃葡糖基	4-O-β-D-glucopyranosyl	[11]
1,4双脱氧-1,4-亚氨基-(2-O-β-D-吡喃葡糖基)-D-阿拉伯糖醇	1,4-dideoxy-1,4-imino-(2-0-B-D-glucopyranosyl)-D-arabinitol	[12]
荞麦碱(FAG)	fagomine	[12]
3-表荞麦碱	3-epi-fagomine	[12]
打碗花精B2	calysteginB2	[12]
1,4双脱氧-1,4-亚氨基-D-阿拉伯糖醇(DAB)	1,4-dideoxy-1,4-mino-D-arabinitol	[12]
2-O-β-D-吡喃葡糖基-1-脱氧野尻霉素	2-O-(B-D-glucopyranosyl)-1-deoxynojirimycin	[12]
6-O-β-D-吡喃葡糖基-1-脱氧野尻霉素	6-O-(B-D-glucopyranosyl)-1-Deoxynojirimycin	[12]
2-O-(α-d-吡喃半乳糖基)-1-脱氧野尻霉素	2-O-(α-d-galactopyranosyl)-1-deoxynojirimycin	[12]

提取方法	提取条件	参考文献
超声波辅助乙醇溶剂提取法	提取时间20 min,提取温度60 ℃,料液比1∶20,超声功率800 W,乙醇浓度60%	[23]
乙醇溶剂常温浸提法	提取液25% 乙醇-0. 05 mol·L^-1盐酸,常温浸提 3 h,提取两次	[24]
水提醇沉法	加水煎煮浓缩,加70%乙醇,静置过夜,回收乙醇	[25]
微波辅助提取法	微波功率406 W(中火)、微波处理时间1.5 min、固液比(g·mL^-1)1∶40、提取次数2次	[26]

提取方法	提取条件	参考文献
超声波辅助乙醇溶剂提取法	提取时间20 min,提取温度60 ℃,料液比1∶20,超声功率800 W,乙醇浓度60%	[23]
乙醇溶剂常温浸提法	提取液25% 乙醇-0. 05 mol·L^-1盐酸,常温浸提 3 h,提取两次	[24]
水提醇沉法	加水煎煮浓缩,加70%乙醇,静置过夜,回收乙醇	[25]
微波辅助提取法	微波功率406 W(中火)、微波处理时间1.5 min、固液比(g·mL^-1)1∶40、提取次数2次	[26]

基因表达	变化	参考文献
Ser473-AKT	促进磷酸化	[41]
p85-PI3K	促进磷酸化	[41]
Tyr1361-IR-β	促进磷酸化	[41]
Tyr612-IRS1	促进磷酸化	[41]
SGLT1	下降	[43]
Na1/K1-ATP	下降	[43]
GLUT2	下降	[43]
GK	增强	[43]
PFK	增强	[43]
PK mRNA	增强	[43]
PDE1	增强	[43]
PEPCK	下降	[43]
G-6-Pase	下降	[43]
GLUT4	增强	[41,44]
AdipoR1	增强	[44]
AdipoR2	增强	[44]
ATP1A	降低	[45]
CAMK2	降低	[45]