真菌组蛋白H3K4甲基化在植物与真菌互作中的作用

doi:10.16178/j.issn.0528-9017.20250076

摘要/Abstract

摘要：

组蛋白H3K4甲基化(H3K4me)是表观遗传调控的核心机制之一,通过动态修饰染色质结构,广泛参与真菌与植物的互作过程。本文综述了H3K4甲基化的分子机制,包括由KMT2家族甲基转移酶和JmjC/LSD去甲基化酶介导的动态平衡网络,重点探讨H3K4甲基化如何通过调控真菌基因表达从而影响真菌的生长发育、次生代谢物生产、致病性与环境适应性等多个方面。未来研究需深入揭示H3K4甲基化在植物共生真菌中的功能,并探索其与其他表观遗传修饰的协同调控网络,为开发靶向表观遗传的病害防控策略及真菌次生代谢产物提供理论依据。

关键词: 组蛋白H3K4甲基化, 表观遗传调控, 植物-真菌互作, 次生代谢

Abstract:

Histone H3K4 methylation (H3K4me) is one of the core mechanisms of epigenetic regulation. It dynamically modifies chromatin structure and is widely involved in the interaction between fungi and plants. This paper reviewed the molecular mechanisms of H3K4 methylation, including the dynamic equilibrium network mediated by KMT2 family transmethylase and JmjC/LSD demethylases. It also focused on the effects of H3K4 methylation on fungal growth and development, secondary metabolites production, pathogenicity, and environmental adaptability through fungal gene expression regulation. Future research needs to further elucidate the functions of H3K4 methylation in plant symbiotic fungi and explore its synergistic regulatory networks with other epigenetic modifications, which will provide a theoretical basis for the development of epigenetic-targeted disease control strategies and the exploitation of fungal secondary metabolites.

Key words: histone H3K4 methylation, epigenetic regulation, plant-fungal interaction, secondary metabolism

中图分类号:

S432.44

张瑜, 谢心雨, 孟威. 真菌组蛋白H3K4甲基化在植物与真菌互作中的作用[J]. 浙江农业科学, 2026, 67(1): 143-147.

ZHANG Yu, XIE Xinyu, MENG Wei. Role of fungal histone H3K4 methylation in plant-fungal interactions[J]. Journal of Zhejiang Agricultural Sciences, 2026, 67(1): 143-147.

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