浙江农业科学 ›› 2023, Vol. 64 ›› Issue (12): 2970-2976.DOI: 10.16178/j.issn.0528-9017.20230932
收稿日期:
2022-09-05
出版日期:
2023-12-11
发布日期:
2023-12-14
通讯作者:
李楠(1981—),女,吉林白山人,实验师,硕士,研究方向为植物次生代谢与调控,E-mail: meinv-linan@163.com。
作者简介:
杨小雨(1998—),女,山东烟台人,硕士研究生,研究方向为羊栖菜生理生态,E-mail:1318252780@qq.com。
Received:
2022-09-05
Online:
2023-12-11
Published:
2023-12-14
摘要:
羊栖菜(Sargassum fusiforme)是我国沿海常见的经济褐藻,营养丰富,且具有较高的食用和药用价值。近年来,国内外学者对羊栖菜进行了深入系统的研究。本文综述了国内外学者从羊栖菜中分离到的主要次生代谢产物,包括多酚、甾醇、萜类、色素和凝集素等;总结归纳了各类产物生物活性的研究进展,包括抗氧化、抗菌、抗炎、抗糖尿病、光保护、抗肿瘤、神经保护和抗病毒等,以期为羊栖菜次生代谢产物进一步开发和应用提供理论参考。
中图分类号:
杨小雨, 曹鹏, 邹慧熙, 阎秀峰, 李楠. 羊栖菜次生代谢产物及其活性研究进展[J]. 浙江农业科学, 2023, 64(12): 2970-2976.
[1] | 张展, 刘建国, 刘吉东. 羊栖菜的研究述评[J]. 海洋水产研究, 2002, 23(3): 67-74. |
[2] | SHIN H C, HWANG H J, KANG K J, et al. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava[J]. Archives of Pharmacal Research, 2006, 29(2): 165-171. |
[3] | 严小军. 中国常见褐藻的多酚含量测定[J]. 海洋科学集刊, 1996(1): 61-65. |
[4] | DANG T T, BOWYER M C, VAN ALTENA I A, et al. Comparison of chemical profile and antioxidant properties of the brown algae[J]. International Journal of Food Science & Technology, 2018, 53(1): 174-181. |
[5] | 张丽斌, 熊何健, 吴靖娜, 等. 褐藻多酚的生物活性及提取技术研究进展[J]. 福建水产, 2013, 35(6): 480-484. |
[6] | LI Y J, FU X T, DUAN D L, et al. Extraction and identification of phlorotannins from the brown alga, Sargassum fusiforme (Harvey) setchell[J]. Marine Drugs, 2017, 15(2): 49. |
[7] | HWANG E, PARK S Y, SUN Z W, et al. The protective effects of fucosterol against skin damage in UVB-irradiated human dermal fibroblasts[J]. Marine Biotechnology, 2014, 16(3): 361-370. |
[8] | HOANG M H, JIA Y Y, JUN H J, et al. Fucosterol is a selective liver X receptor modulator that regulates the expression of key genes in cholesterol homeostasis in macrophages, hepatocytes, and intestinal cells[J]. Journal of Agricultural and Food Chemistry, 2012, 60(46): 11567-11575. |
[9] | ZHEN X H, QUAN Y C, JIANG H Y, et al. Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects[J]. European Journal of Pharmacology, 2015, 768: 131-138. |
[10] | CHEN Z, LIU J, FU Z F, et al. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist[J]. Journal of Agricultural and Food Chemistry, 2014, 62(26): 6130-6137. |
[11] | CATALAN C A N, KOKKE W C M C, DUQUE C, et al. Synthesis of (24R)- and (24S)-5, 28-stigmastadien-3.beta.-ol and determination of the stereochemistry of their 24-hydroxy analogs, the saringosterols[J]. The Journal of Organic Chemistry, 1983, 48(26): 5207-5214. |
[12] | JIN H G, ZHOU M, JIN Q H, et al. Antidepressant-like effects of saringosterol, a sterol from Sargassum fusiforme by performing in vivo behavioral tests[J]. Medicinal Chemistry Research, 2017, 26(5): 909-915. |
[13] | SEONG S H, NGUYEN D H, WAGLE A, et al. Experimental and computational study to reveal the potential of non-polar constituents from Hizikia fusiformis as dual protein tyrosine phosphatase 1B and α-glucosidase inhibitors[J]. Marine Drugs, 2019, 17(5): 302. |
[14] | WANG S Y, XIANG J, HUANG X J, et al. Chemical constituents from Sargassum fusiforme (Harv.) setch[J]. Chemistry & Biodiversity, 2020, 17(6): e2000182. |
[15] | KIM E A, LEE J H, HEO S J, et al. Saringosterol acetate isolated from Hizikia fusiforme, an edible brown alga, suppressed hepatocellular carcinoma growth and metastasis in a zebrafish xenograft model[J]. Chemico-Biological Interactions, 2021, 335: 109362. |
[16] | AVALOS M, GARBEVA P, VADER L, et al. Biosynthesis, evolution and ecology of microbial terpenoids[J]. Natural Product Reports, 2022, 39(2): 249-272. |
[17] | 徐忠明. 羊栖菜中萜类成分的提取与纯化方法研究[D]. 杭州: 浙江工商大学, 2015. |
[18] | 王海阳. 羊栖菜的化学成分及生物活性研究[D]. 大连: 大连工业大学, 2015. |
[19] | ZHANG H, TANG Y B, ZHANG Y, et al. Fucoxanthin: a promising medicinal and nutritional ingredient[J]. Evidence-Based Complementary and Alternative Medicine, 2015, 2015: 723515. |
[20] | MAEDA H, HOSOKAWA M, SASHIMA T, et al. Antiobesity effect of fucoxanthin from edible seaweeds and its multibiological functions[M]//ACS Symposium Series. Washington, DC: American Chemical Society, 2008: 376-388. |
[21] | 汪曙晖, 薛长湖. 岩藻黄素的结构、性质和功能[J]. 食品工业科技, 2010, 31(6): 408-410, 407. |
[22] | 尹尚军, 徐涛, 刘丽平, 等. 羊栖菜岩藻黄质的提取工艺研究[J]. 食品工业科技, 2011, 32(4): 272-275. |
[23] | 刘丽平. 羊栖菜岩藻黄质的提取及理化性质研究[D]. 杭州: 浙江理工大学, 2012. |
[24] | XIAO X H, SI X X, YUAN Z Q, et al. Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography[J]. Journal of Separation Science, 2012, 35(17): 2313-2317. |
[25] | CHEN D T, JIN Y T, HU D, et al. One-step preparative separation of fucoxanthin from three edible brown algae by elution-extrusion countercurrent chromatography[J]. Marine Drugs, 2022, 20(4): 257. |
[26] | DAI Y L, JIANG Y F, LU Y, et al. Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation in vitro and in vivo[J]. Toxicology Reports, 2021, 8: 349-358. |
[27] | YANG W C, ZHANG Y Y, LI Y J, et al. Chemical composition and anti-alzheimer's disease-related activities of a functional oil from the edible seaweed Hizikia fusiforme[J]. Chemistry & Biodiversity, 2020, 17(8): e2000055. |
[28] | WU M J, TONG C Q, WU Y, et al. A novel thyroglobulin-binding lectin from the brown alga Hizikia fusiformis and its antioxidant activities[J]. Food Chemistry, 2016, 201: 7-13. |
[29] | WEIS W I, DRICKAMER K. Structural basis of lectin-carbohydrate recognition[J]. Annual Review of Biochemistry, 1996, 65: 441-473. |
[30] | LIU N, FU X, DUAN D, et al. Evaluation of bioactivity of phenolic compounds from the brown seaweed of Sargassum fusiforme and development of their stable emulsion[J]. Journal of Applied Phycology, 2018, 30(3): 1955-1970. |
[31] | 杨小青, 卢虹玉, 李延平, 等. 羊栖菜不同分子质量褐藻多酚抗氧化活性研究[J]. 海洋科学, 2013, 37(4): 47-51. |
[32] | 何传辉. 羊栖菜多酚的分离纯化与功能活性研究[D]. 厦门: 集美大学, 2016. |
[33] | 许亚如. 褐藻多酚的抗氧化活性研究[D]. 宁波: 宁波大学, 2014. |
[34] | 孙瑜, 丁国芳, 徐银峰. 海洋褐藻羊栖菜(Sargassum fusiforme)中马尾藻甾醇、岩藻甾醇的分类纯化及抗菌、抗氧化活性研究[J]. 海洋与湖沼, 2017, 48(3): 640-646. |
[35] | 杨文聪. 海洋真菌及海藻羊栖菜来源的抗AD等活性成分研究[D]. 湛江: 广东海洋大学, 2018. |
[36] | 范晓, 严小军, 房国明, 等. 高分子量褐藻多酚抗氧化性质研究[J]. 水生生物学报, 1999, 23(5): 494-499. |
[37] | AUDIBERT L, FAUCHON M, BLANC N, et al. Phenolic compounds in the brown seaweed Ascophyllum nodosum: distribution and radical-scavenging activities[J]. Phytochemical Analysis, 2010, 21(5): 399-405. |
[38] | FERRERES F, LOPES G, GIL-IZQUIERDO A, et al. Phlorotannin extracts from fucales characterized by HPLC-DAD-ESI-MSn: approaches to hyaluronidase inhibitory capacity and antioxidant properties[J]. Marine Drugs, 2012, 10(12): 2766-2781. |
[39] | HERMUND D B, PLAZA M, TURNER C, et al. Structure dependent antioxidant capacity of phlorotannins from Icelandic Fucus vesiculosus by UHPLC-DAD-ECD-QTOFMS[J]. Food Chemistry, 2018, 240: 904-909. |
[40] | OKTAVIANI D F, BAE Y S, MEINITA M, et al. An ethanol extract of the brown seaweed Hizikia fusiformis and its active constituent, fucosterol, extend the lifespan of the nematode caenorhabditis elegans[J]. Korean Society of Life Science, 2019, 29(10): 1120-1125. |
[41] | YAN X, CHUDA Y, SUZUKI M, et al. Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed[J]. Bioscience, Biotechnology, and Biochemistry, 1999, 63(3): 605-607. |
[42] | 汪财生, 王璐, 刘丽平, 等. 羊栖菜岩藻黄质色素的抗氧化性研究[J]. 食品工业科技, 2012, 33(23): 125-128. |
[43] | WU M J, WU Y E, TONG C Q, et al. Antibacterial total phenolic compounds from a brown alga Hizikia fusiformis[J]. DEStech Transactions on Environment, Energy and Earth Sciences, 2017: 418-425. |
[44] | TANG J L, WANG W Q, CHU W H. Antimicrobial and anti-quorum sensing activities of phlorotannins from seaweed (Hizikia fusiforme)[J]. Frontiers in Cellular and Infection Microbiology, 2020, 10: 586750. |
[45] | 任俊丽, 路远, 南海函, 等. 羊栖菜抗水产动物致病性海洋弧菌活性成分研究[J]. 温州医学院学报, 2011, 41(2): 107-111. |
[46] | 林雄平, 郑怡, 陈晓清. 羊栖菜提取物抗动植物病原菌活性及化学成分初步分析[J]. 热带海洋学报, 2009, 28(2): 77-80. |
[47] | 刘艳如, 王缨, 林勇, 等. 羊栖菜提取物对食用菌竞争性杂菌生长的抑制作用[J]. 福建农业学报, 2008, 23(3): 270-273. |
[48] | ROBLES CENTENO P O, BALLANTINE D. Effects of culture conditions on production of antibiotically active metabolites by the marine alga Spyridia filamentosa (Ceramiaceae, Rhodophyta). I. Light[J]. Journal of Applied Phycology, 1998, 10(2): 453-460. |
[49] | BUCKLEY C D, GILROY D W, SERHAN C N, et al. The resolution of inflammation[J]. Nature Reviews Immunology, 2013, 13(1): 59-66. |
[50] | 黄平, 洪静霞, 米杰, 等. 羊栖菜多酚通过核转录因子-κB/丝裂原活化蛋白激酶通路缓解脂多糖诱导的RAW264.7细胞炎症反应[J]. 食品科学, 2022, 43(23): 141-148. |
[51] | YANG E J, MOON J Y, KIM M J, et al. Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7[J]. Journal of Zhejiang University Science B, 2010, 11(5): 315-322. |
[52] | 倪立颖, 邹娅雪, 付晓婷, 等. 利用LPS诱导胚胎期斑马鱼炎症模型研究羊栖菜多酚抗炎机制[J]. 食品工业科技, 2019, 40(21): 279-285. |
[53] | LEE K H, KIM H J, KIM H B, et al. Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2, 4-dinitrochlorobenzene-treated BALB/c mice[J]. The Journal of Pharmacy and Pharmacology, 2014, 66(3): 466-476. |
[54] | HWANG E, PARK S Y, SHIN H S, et al. Effect of oral administration of fucosterol from Hizikia fusiformis on DNCB-induced atopic dermatitis in NC/Nga mice[J]. Food Science and Biotechnology, 2014, 23(2): 593-599. |
[55] | LEE S G, KANG H. Evaluation of antioxidant and anti-neuroinflammatory activities of Hizikia fusiformis (Harvey) Okamura extract[J]. Tropical Journal of Pharmaceutical Research, 2015, 14(3): 463. |
[56] | WU S Y, ZUO J H, CHENG Y, et al. Ethanol extract of Sargarsum fusiforme alleviates HFD/STZ-induced hyperglycemia in association with modulation of gut microbiota and intestinal metabolites in type 2 diabetic mice[J]. Food Research International, 2021, 147: 110550. |
[57] | 王淼. 羊栖菜乙酸乙酯部位中的化学成分研究[D]. 大连: 大连工业大学, 2017. |
[58] | SOLANO F. Photoprotection and skin pigmentation: melanin-related molecules and some other new agents obtained from natural sources[J]. Molecules, 2020, 25(7): 1537. |
[59] | 曾帅. 羊栖菜多酚分离纯化及对小鼠成纤维细胞抗紫外损伤影响[D]. 上海: 上海海洋大学, 2016. |
[60] | 王长秀, 刘义, 林满华. 羊栖菜褐藻多酚对S180荷瘤小鼠抗肿瘤作用的实验研究[J]. 广东医学院学报, 2014, 32(5): 614-616. |
[61] | 李亚娴. 羊栖菜多酚粗品的纯化及其抗肿瘤活性研究[D]. 大连: 大连海洋大学, 2016. |
[62] | KIM S O, CHOI Y H. The ethyl alcohol extract of Hizikia fusiforme inhibits matrix metalloproteinase activity and regulates tight junction related protein expression in Hep3B human hepatocarcinoma cells[J]. Journal of Medicinal Food, 2010, 13(1): 31-38. |
[63] | PARK C, LEE H, HWANGBO H, et al. Ethanol extract of Hizikia fusiforme induces apoptosis in B16F10 mouse melanoma cells through ROS-dependent inhibition of the PI3K/akt signaling pathway[J]. Asian Pacific Journal of Cancer Prevention, 2020, 21(5): 1275-1282. |
[64] | CHOI Y, CHOI E, LEE H, et al. Ethanol extracts of Hizikia fusiforme induce apoptosis in human prostate cancer PC3 cells via modulating a ROS-dependent pathway[J]. Asian Pacific Journal of Tropical Biomedicine, 2020, 10(2): 78. |
[65] | KIM T Y, JIN C Y, KIM G Y, et al. Ethyl alcohol extracts of Hizikia fusiforme sensitize AGS human gastric adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis[J]. Journal of Medicinal Food, 2009, 12(4): 782-787. |
[66] | SON Y S, ARIF ULLAH H M, ELFADL A K, et al. Inhibition of formation of azoxymethane-induced colonic aberrant crypt foci in rats by edible green algae Capsosiphon fulvescens and brown algae Hizikia fusiforme[J]. In Vivo, 2018, 32(1): 101-108. |
[67] | WAGLE A, SEONG S H, ZHAO B T, et al. Comparative study of selective in vitro and in silico BACE1 inhibitory potential of glycyrrhizin together with its metabolites, 18α- and 18β-glycyrrhetinic acid, isolated from Hizikia fusiformis[J]. Archives of Pharmacal Research, 2018, 41(4): 409-418. |
[68] | 黎燕媚, 聂影影, 刘亚月, 等. 羊栖菜抑制乙酰胆碱酯酶活性油脂成分的提取优化[J]. 广东海洋大学学报, 2022, 42(3): 97-106. |
[69] | BOGIE J, HOEKS C, SCHEPERS M, et al. Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model[J]. Scientific Reports, 2019, 9(1): 4908. |
[70] | MARTENS N, SCHEPERS M, ZHAN N, et al. 24(S)-saringosterol prevents cognitive decline in a mouse model for Alzheimer's disease[J]. Marine Drugs, 2021, 19(4): 190. |
[71] | 顾丽霞, 潘成燕, 赵水莲, 等. 海藻羊栖菜不同分子质量多酚抗抑郁活性研究[J]. 时珍国医国药, 2015, 26(2): 272-274. |
[72] | LEE D Y W, LIN X D, PASKALEVA E E, et al. Palmitic acid is a novel CD4 fusion inhibitor that blocks HIV entry and infection[J]. AIDS Research and Human Retroviruses, 2009, 25(12): 1231-1241. |
[73] | CHATHURANGA K, WEERAWARDHANA A, DODANTENNA N, et al. Inhibitory effect of Sargassum fusiforme and its components on replication of respiratory syncytial virus in vitro and in vivo[J]. Viruses, 2021, 13(4): 548. |
[74] | PARK S Y, HWANG E, SHIN Y K, et al. Immunostimulatory effect of enzyme-modified Hizikia fusiforme a mouse model in vitro and ex vivo[J]. Marine Biotechnology, 2017, 19(1): 65-75. |
[75] | KIM M E, CHO J H, JUNG I, et al. Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo[J]. Bioscience, Biotechnology, and Biochemistry, 2020, 84(9): 1861-1869. |
[76] | HUH G W, LEE D Y, IN S J, et al. Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63[J]. Journal of the Korean Society for Applied Biological Chemistry, 2012, 55(4): 551-555. |
[77] | NATARAJAN A, JAYAVELU A, THANGAMANI R, et al. In vivo evaluation of protective effect of Sargassum fusiforme on cisplatin induced hepato-renal toxicity[J]. Physiological and Molecular Plant Pathology, 2022, 117: 101748. |
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