Research progress of Kunitz-type serine protease inhibitors

doi:10.16178/j.issn.0528-9017.20240664

Abstract

Abstract:

Kunitz-type serine protease inhibitors are widely found in nature and consist of one or more Kunitz domains, which are usually composed of two α-helices, a pair of antiparallel β-pleated sheets, a β-turn, and two loops, with 2-3 conserved disulfide bonds. These proteins containing Kunitz domains tightly bind to serine proteases in a substrate-like manner, effectively blocking the active site of the enzyme and inhibiting its activity. This article reviewd the important role of these inhibitors in anti-tumor, anti-coagulation, anti-inflammation, anti-microbial and so on.

Key words: Kunitz-type serine protease inhibitor, structure, function

CLC Number:

TQ464.8

ZHANG Hongyan, JIN Can, LUO Wen. Research progress of Kunitz-type serine protease inhibitors[J]. Journal of Zhejiang Agricultural Sciences, 2025, 66(7): 1770-1778.

Figures/Tables 1

References 66

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