[1] GALANIS A, PAPPA A, GIANNAKAKIS A, et al.Reactive oxygen species and HIF-1 signalling in cancer[J]. Cancer Letters, 2008, 266(1):12-20. [2] BRAHIMIHORN C, MAZURE N, POUYSSÉGUR J. Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications[J]. Cellular Signalling, 2005, 17(1):1-9. [3] KIM J W, TCHERNYSHYOV I, SEMENZA G L, et al.HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia[J]. Cell Metabolism, 2006, 3(3):177-185. [4] SUNDARAM S S, HALBOWER A, PAN Z, et al.Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease[J]. Journal of Hepatology, 2016, 65(3):560-569. [5] ARMSTRONG M B, TOWLE H C.Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway[J]. American Journal of Physiology Endocrinology & Metabolism, 2001, 281(6): 1197-1204. [6] LIU Y L, MA Z H, ZHAO C Q, et al.HIF-1 and HIF-2 are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1 mediated fatty acid oxidation[J]. Toxicology Letters, 2014,226:117-123. [7] 路瑛丽, 张漓, 冯连世,等. 高住高练和高住低练对大鼠血脂及腓肠肌脂肪酸氧化的影响[J]. 中国运动医学杂志, 2010, 29(2):137-140. [8] TAI C C, DING S T.N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention[J]. Journal of Nutritional Biochemistry, 2010, 21(5):357-363. [9] LOMBARDO Y B, CHICCO A G.Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review[J]. Journal of Nutritional Biochemistry, 2006, 17(1):1-13. [10] LIPPL F J, NEUBAUER S, SCHIPFER S, et al.Hypobaric hypoxia causes body weight reduction in obese subjects[J]. Obesity, 2012, 18(4):675-681. [11] YAN X, ZHANG J, WENG X.Appetite at high altitude: an fMRI study on the impact of prolonged high-altitude residence on gustatory neural processing[J]. Experimental Brain Research, 2011, 209(4):495-499. [12] XIONG Y L, QU Z, CHEN N, et al.The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue[J]. Molecular & Cellular Endocrinology, 2014, 392(1/2):106-114. [13] HASHIMOTO T, YOKOKAWA T, ENDO Y, et al.Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes[J]. Biochemistry Biophysiology Research Communication, 2013, 440(1):43-49. [14] ARMSTRONG E H, GOSWAMI D, GRIFFIN P R, et al.Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway[J]. Journal of Biological Chemistry, 2014, 289(21):14941-14954. [15] 赵成玉, 圈启芳, 何熠伟,等. 慢性持续性低氧对大鼠肝脏和胰腺GLUT2 mRNA 表达的影响[J]. 中华临床医师杂志:电子版, 2015(22):4148-4152. [16] CARRERAS A, KAYALI F, ZHANG J, et al.Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period[J]. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2012, 303(7): 700-709. [17] YIN J, GAO Z, HE Q, et al.Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue[J]. American Journal of Physiology-Endocrinology and Metabolism, 2009, 296(2): 333-342. [18] LECOULTRE V, BOSS A, TAPPY L, et al.Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exercise[J]. Experimental Physiology, 2010, 95(2):315-330. [19] YU S, LEVI L, CASADESUS G, et al.Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain[J]. Journal of Biological Chemistry, 2014, 289(18):12748-12758. [20] GLADINE C, ROY N C, RIGAUDIÈRE J P, et al. Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner[J]. British Journal of Nutrition, 2012, 107(9):1254-1273. [21] MUNRO I A, GARG M L.Dietary supplementation with long chain omega-3 polyunsaturated fatty acids and weight loss in obese adults[J]. Obesity Research & Clinical Practice, 2013, 7(3):173-181. [22] FUKUMITSU S, VILLAREAL M O, ONAGA S, et al.α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and-1c expression[J]. Cytotechnology, 2013, 65(6):899-907. [23] BARRENA H C, SCHIAVON F P, CARARRA M A, et al.Effect of linseed oil and macadamia oil on metabolic changes induced by high-fat diet in mice[J]. Cell Biochemistry & Function, 2014, 32(4):333-340. |