Kunitz型丝氨酸蛋白酶抑制剂的研究进展

doi:10.16178/j.issn.0528-9017.20240664

摘要/Abstract

摘要：

Kunitz型丝氨酸蛋白酶抑制剂广泛存在于自然界,其包含1个或多个Kunitz结构域,该结构域通常是由2段α螺旋,一对反向平行的β折叠,β转角和2个环以及2~3对保守的二硫键组成。这些含Kunitz结构域的蛋白通过与丝氨酸蛋白酶以一种类似底物的方式紧密结合,阻断了丝氨酸蛋白酶的活性位点,从而抑制了酶的活性。本文综述了这类抑制剂在抗肿瘤、抗凝血、抗炎、抗微生物等方面发挥的重要作用。

关键词: Kunitz型丝氨酸蛋白酶抑制剂, 结构, 功能

Abstract:

Kunitz-type serine protease inhibitors are widely found in nature and consist of one or more Kunitz domains, which are usually composed of two α-helices, a pair of antiparallel β-pleated sheets, a β-turn, and two loops, with 2-3 conserved disulfide bonds. These proteins containing Kunitz domains tightly bind to serine proteases in a substrate-like manner, effectively blocking the active site of the enzyme and inhibiting its activity. This article reviewd the important role of these inhibitors in anti-tumor, anti-coagulation, anti-inflammation, anti-microbial and so on.

Key words: Kunitz-type serine protease inhibitor, structure, function

中图分类号:

TQ464.8

张红燕, 金参, 罗文. Kunitz型丝氨酸蛋白酶抑制剂的研究进展[J]. 浙江农业科学, 2025, 66(7): 1770-1778.

ZHANG Hongyan, JIN Can, LUO Wen. Research progress of Kunitz-type serine protease inhibitors[J]. Journal of Zhejiang Agricultural Sciences, 2025, 66(7): 1770-1778.

图/表 1

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